Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

Cellular adaptation to hypoxia is a trademark of most cancers, however the relative contribution of hypoxia-inducible components (HIFs) versus different oxygen sensors to tumorigenesis is unclear. We make use of a multi-omics pipeline together with measurements of nascent RNA to characterize transcriptional adjustments upon acute hypoxia. We determine an instantaneous early transcriptional response that’s strongly …

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