Genetic analysis of SLC26A4 gene (pendrin) related deafness among a cohort of assortative mating families from southern India.

Assortative mating (AM) or preferential mating is known to influence the genetic architecture of the hearing-impaired (HI) population. AM is now seen as a universal phenomenon with individuals seeking partners based on quantitative, qualitative, and behavioral phenotypes.

However, the molecular genetic dynamics of AM among the HI tested in real time are limited to the DFNB1 locus.A total of 113 HI partners from 82 South Indian families (52 deaf marrying deaf and 30 deaf marrying normal), previously excluded for DFNB1 (GJB2/6) etiology, were screened for SLC26A4 gene (DFNB4) variants.A spectrum of seven pathogenic variants viz., p.S90L, p.V239D, p.V359E, p.Gly389Trpfs*79 (novel), p.T410M, p.N457K and p.K715N were identified.

The pathogenic allele frequency of SLC26A4 variants identified in this study was 3.98% (9/226).We recommend a preliminary screening of mutational hotspots for future investigations to rapidly test for its recurrence among South Indian HI population. This will be the first study to comprehensively account for the incidence of SLC26A4 gene variants and the real-time dynamics of DFNB4 variants among this type of a HI cohort.

SKT siRNA

20-abx933470
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

SKT (KIAA1217) Antibody

abx234542-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

HSP70 ELISA Kit (PLANT)

SKT-124-96 1 plate of 96 wells
EUR 717
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
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Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

HSP70 ELISA Kit

SKT-105-480 5 plates of 96 wells
EUR 2260
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
  • Show more
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit

SKT-106-480 5 plates of 96 wells
EUR 2836
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
  • Show more
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit

SKT-107-480 5 plates of 96 wells
EUR 2702
  • HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral componen
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Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)

SKT-108-480 5 plates of 96 wells
EUR 2702
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
  • Show more
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit

SKT-109-480 5 plates of 96 wells
EUR 2277
  • HSP27s belong to an abundant and ubiquitous family of small heat shock proteins (sHSP). It is an important HSP found in both normal human cells and cancer cells. The basic structure of most sHSPs is a homologous and highly conserved amino acid sequen
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Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit

SKT-110-480 5 plates of 96 wells
EUR 2277
  • In both prokaryotic and eukaryotic cells, the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones. Members of the HSP60 family of heat shock proteins are some of the b
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Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit

SKT-111-480 5 plates of 96 wells
EUR 2277
  • Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is seq
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Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit

SKT-113-480 5 plates of 96 wells
EUR 2478
  • HSP65 is a member of the HSP60 family of heat shock proteins (2, 3). HSP60s are mitochondrial chaperonins that are typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In additi
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Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit

SKT-123-480 5 plates of 96 wells
EUR 2836
  • The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mamma
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Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

Nitrotyrosine ELISA Kit

SKT-126-480 5 plates of 96 wells
EUR 1747
  • Nitrotyrosine has been identified as a marker of inflammation and NO production. Nitrotyrosine is formed in presence of the active metabolite NO. Various pathways including the formation of peroxinitrite lead to nitrotyrosine production. Since nitrot
  • Show more
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit

SKT-137-480 5 plates of 96 wells
EUR 2474
  • GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the p
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Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit

SKT-140-480 5 plates of 96 wells
EUR 2195
  • Dibromo-tyrosine is produced by the oxidative bromination of tyrosine residues. This reaction occurs via eosinophil peroxidase (EPO), an enzyme released by activated eosinophils. Upon activation of eosinophils, a respiratory burst occurs releasing el
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Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Mouse SKT shRNA Plasmid

20-abx980555
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

JW 480

B5556-10 10 mg
EUR 167

JW 480

B5556-25 25 mg
EUR 325

JW 480

B5556-5 5 mg
EUR 110

JW 480

B5556-50 50 mg
EUR 540

Mouse pre-microRNA Expression Construct mir-124-1

MMIR-124-1-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Mouse pre-microRNA Expression Construct mir-124-2

MMIR-124-2-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Mouse pre-microRNA Expression Construct mir-124-3

MMIR-124-3-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Augmedium™, Powder 500

124 500 ml
EUR 566

Sulforhodamine 101 sulfonyl chloride [Texas Red®] *CAS 82354-19-6*

480 10 mg
EUR 132
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12171501

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96 Tests
EUR 865

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

EUK-124

2174-25
EUR 262

EUK-124

2174-5
EUR 109

PTC-124

9421-10
EUR 142

PTC-124

9421-50
EUR 414

CHIR-124

E1KS2683 2mg1​ PHYSICAL AND CHEMICAL PROPERTIES
EUR 325

EUK 124

C4679-10 10 mg
EUR 132

FPA 124

B7222-10 10 mg
EUR 241

FPA 124

B7222-25 25 mg
EUR 457

FPA 124

B7222-5 5 mg
EUR 158

CHIR-124

A8394-25 25 mg
EUR 340
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M.

CHIR-124

A8394-5 5 mg
EUR 151
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M.

CHIR-124

A8394-5.1 10 mM (in 1mL DMSO)
EUR 160
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M.

CHIR-124

A8394-50 50 mg
EUR 537
Description: CHIR-124, a selective inhibitor, inhibits Chk1 with IC50 value of 0.3nM 2,000-fold more potently than Chk2 with IC50 value of 0.7?M.

CHIR-124

HY-13263 50mg
EUR 670

FPA-124

HY-15369 5mg
EUR 394

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96 Tests
EUR 824

Handheld Fluorometer 480/530nm

FL480530 1 unit
EUR 1572
Description: Compact handheld fluorometer (exc.480 and em.530nm) for quantitative determination of various analytes in life sciences R&D, food safety and environmental monitoring. Highly sensitive, rapid-reading, reliable and low cost.

miRZip-124 anti-miR-124 microRNA construct

MZIP124-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit

EF014796 96 Tests
EUR 689

Polyclonal ADD3 Antibody (aa431-480)

APR14821G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD3 (aa431-480). This antibody is tested and proven to work in the following applications:

Anti-DDX41 (aa468-480) antibody

STJ73402 100 µg
EUR 359

SSEA-1 Antibody (Clone MC-480)

3063-25
EUR 272

Polyclonal TAOK1 / TAO1 Antibody (aa431-480)

AMM08087G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TAOK1 / TAO1 (aa431-480). This antibody is tested and proven to work in the following applications:

Zinc Finger Protein 480 (ZNF480) Antibody

20-abx116741
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Zinc Finger Protein 480 (ZNF480) Antibody

abx030192-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Zinc Finger Protein 480 (ZNF480) Antibody

abx030192-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Myosin Light Chain Kinase (480-501)

H-3554.0500 0.5mg
EUR 273
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

Myosin Light Chain Kinase (480-501)

H-3554.1000 1.0mg
EUR 466
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

Akt (Ab-124) Antibody

33129-100ul 100ul
EUR 252

Akt (Ab-124) Antibody

33129-50ul 50ul
EUR 187

AKT1 (Ab-124) Antibody

CSB-PA919481-
EUR 335
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against AKT1 (Ab-124). Recognizes AKT1 (Ab-124) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

AKT1 (Ab-124) Antibody

CSB-PA919481-100ul 100ul
EUR 316
  • Form: liquid
  • Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific
  • Show more
Description: A polyclonal antibody against AKT1 (Ab-124). Recognizes AKT1 (Ab-124) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

bcl-2(124) Antibody

BNUB0530-100 100uL
EUR 209
Description: Primary antibody against bcl-2(124), Concentration: 0.2mg/mL

bcl-2(124) Antibody

BNUB0530-500 500uL
EUR 458
Description: Primary antibody against bcl-2(124), Concentration: 0.2mg/mL

bcl-2(124) Antibody

BNUM0530-50 50uL
EUR 395
Description: Primary antibody against bcl-2(124), 1mg/mL

bcl-2(124) Antibody

BNC040530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF405S conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC040530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF405S conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC550530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF555 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC550530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF555 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC610530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC610530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF660R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC470530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC470530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF647 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC050530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF405M conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC050530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF405M conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC400530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF640R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC400530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF640R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC430530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF543 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC430530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF543 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC800530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF680 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC800530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF680 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCP0530-250 250uL
EUR 383
Description: Primary antibody against bcl-2(124), PerCP conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCR0530-250 250uL
EUR 383
Description: Primary antibody against bcl-2(124), RPE conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCA0530-250 250uL
EUR 383
Description: Primary antibody against bcl-2(124), APC conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCAP0530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCAP0530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCB0530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCB0530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCH0530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNCH0530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC940530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC940530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF594 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC700530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF770 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC700530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF770 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC880530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC880530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC810530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC810530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC680530-100 100uL
EUR 199
Description: Primary antibody against bcl-2(124), CF568 conjugate, Concentration: 0.1mg/mL

bcl-2(124) Antibody

BNC680530-500 500uL
EUR 544
Description: Primary antibody against bcl-2(124), CF568 conjugate, Concentration: 0.1mg/mL

rno-miR-124 Primers

MP-r00089 150 ul / 10 uM
EUR 176