Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli.

The peptidoglycan cell wall supplies a vital protecting barrier in nearly all micro organism, defining mobile morphology and conferring resistance to osmotic stress and different environmental hazards. The precursor to peptidoglycan, lipid II, is assembled on the internal leaflet of the plasma membrane. However, peptidoglycan polymerization happens on the outer face of the plasma membrane, […]